Advertisement
Case Report|Articles in Press

Advent of paradoxical flow after antihypertensive treatment in mid-ventricular obstructive hypertrophic cardiomyopathy – A case report

Published:January 25, 2023DOI:https://doi.org/10.1016/j.jccase.2023.01.003

      Abstract

      A 69-year-old woman was admitted our hospital due to acute cerebral infarction. Transthoracic echocardiography showed massive left ventricular (LV) hypertrophy with small ventricles and normal LV ejection fraction. Apical 4-chamber and longitudinal images showed mild LV obstruction. After treatment for hypertension, her blood pressure decreased from 208/129 mmHg to 150/68 mmHg. Pulsed Doppler echocardiography revealed new paradoxical flow at the mid-ventricle. Decreased LV pressure following treatment with antihypertensive medications may have contributed to the development of early mid-ventricular obstruction and paradoxical flow in the present case.

      Learning objective

      In mid-ventricular obstructive cardiomyopathy, apical aneurysm may be present and cause serious complications such as rupture of the apex and sudden death. In the present case, apical aneurysm newly developed after treatment for hypertension was suggested by advent of paradoxical flow. This case suggests that intraventricular hemodynamic change may become a trigger of paradoxical flow and apical aneurysm, becoming a risk of serious complication.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Journal of Cardiology Cases
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Nakamura T.
        • Matsubara K.
        • Furukawa K.
        • Azuma A.
        • Sugihara H.
        • Katsume H.
        • Nakagawa M.
        Diastolic paradoxic jet flow in patients with hypertrophic cardiomyopathy: evidence of concealed apical asynergy with cavity obliteration.
        J Am Coll Cardiol. 1992; 19: 516-524
        • Matsubara K.
        • Nakamura T.
        • Kuribayashi T.
        • Azuma A.
        • Nakagawa M.
        Sustained cavity obliteration and apical aneurysm formation in apical hypertrophic cardiomyopathy.
        J Am Coll Cardiol. 2003; 42: 288-295
        • Misumi I.
        • Honda T.
        • Kurokawa H.
        • Kubota Y.
        • Ishii M.
        • Sato R.
        • Yamabe H.
        • Yasuda H.
        • Kaikita K.
        • Hokimoto S.
        • Ogawa H.
        Systolic flow reversal in a case of mid-ventricular obstructive hypertrophic cardiomyopathy.
        Intern Med. 2015; 54: 1765-1769
        • Takeoka M.
        • Yamano M.
        • Kawasaki T.
        Exercise-induced diastolic paradoxical jet flow in a patient with hypertrophic cardiomyopathy.
        J Cardiol Cases. 2021; 23: 170-172
        • Nakamura T.
        • Kitamura H.
        • Furukawa K.
        • Matsubara K.
        • Katahira T.
        • Okamuro S.
        • Tsuji Y.
        • Takahashi T.
        • Kunishige H.
        • Katsume H.
        • Nakagawa M.
        Intraventricular flow dynamics in hypertrophic cardiomyopathy with midventricular obstruction investigated by doppler echocardiography.
        J Cardiol. 1989; 19 (–71(in Japanese)): 455
        • Tezuka A.
        • Higo K.
        • Nakamukae Y.
        • Nishihara S.
        • Kamikawa M.
        • Shimofuku C.
        • Kawazoe K.
        • Ohishi M.
        Bisoprolol successfully improved the intraventricular pressure gradient in a patient with midventricular obstructive hypertrophic cardiomyopathy with an apex aneurysm due to apical myocardial damage.
        Intern Med. 2019; 58: 535-539
        • McCrohon J.A.
        • Moon J.C.C.
        • Prasad S.K.
        • McKenna W.J.
        • Lorenz C.H.
        • Coats A.J.S.
        • Pennell D.J.
        Differentiation of heart failure related to dilated cardiomyopathy and coronary artery disease using gadolinium-enhanced cardiovascular magnetic resonance.
        Circulation. 2003; 108: 54-59
        • Olbers J.
        • Gille A.
        • Ljungman P.
        • Rosenqvist M.
        • Ostergren J.
        • Witt N.
        High beat-to-beat blood pressure variability in atrial fibrillation compared to sinus rhythm.
        Blood Press. 2018; 27: 249-255
        • Shah A.
        • Duncan K.
        • Winson G.
        • Chaudhry F.A.
        • Sherridet M.A.
        Severe symptoms in mid and apical hypertrophic cardiomyopathy.
        Echocardiography. 2009; 26: 922-933
        • Maron M.S.
        • Finley J.J.
        • Bos J.M.
        • Hauser T.H.
        • Manning W.J.
        • Haas T.S.
        • Lesser J.R.
        • Udelson J.E.
        • Ackerman M.J.
        • Maron B.J.
        Prevalence, clinical significance, and natural history of left ventricular apical aneurysms in hypertrophic cardiomyopathy.
        Circulation. 2008; 118: 1541-1549