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Case Report| Volume 26, ISSUE 3, P186-189, September 2022

Thrombus-in-transit involving all four chambers of the heart in a patient presenting with acute pulmonary embolism

      Abstract

      A 43-year-old male with history of pulmonary embolism defaulted on anti-coagulation and presented with recurrent massive pulmonary embolism. Echocardiography revealed a serpiginous freely floating right atrial thrombus prolapsing through the tricuspid valve into the right ventricle. Thrombus was also seen crossing the interatrial septum into the left atrium and prolapsing into the left ventricle. Right-sided chambers were dilated with right ventricular dysfunction. Left ventricle was functioning normally. After evaluation by the pulmonary embolism response team, thrombolysis was done with alteplase which resulted in dramatic improvement of the symptoms and complete resolution of the intra-cardiac thrombus. Regular follow-up and counselling are advised henceforth to ensure drug compliance.

      Learning objectives

      • 1.
        In patients with right heart thrombus crossing an intracardiac communication into left-sided chambers carries an additional risk.
      • 2.
        Pulmonary embolism response team is essential for clinical decision-making.
      • 3.
        Echocardiography plays a critical role to diagnose and assess the extent of the intracardiac thrombus and ventricular function.
      • 4.
        On computed tomography, right ventricular (RV)/left ventricular diameter ratio of >0.9 and the presence of septal bowing signifies the presence of RV strain.
      • 5.
        Adequate counselling ensuring patient compliance and regular follow up is of utmost importance.

      Keywords

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      References

        • Barrios D.
        • Rosa-Salazar V.
        • Jiménez D.
        • Morillo R.
        • Muriel A.
        • Del Toro J.
        • et al.
        Right heart thrombi in pulmonary embolism.
        Eur. Respir. J. 2016; 48: 1377-1385https://doi.org/10.1183/13993003.01044-2016
        • Torbicki A.
        • Galié N.
        • Covezzoli A.
        • Rossi E.
        • De Rosa M.
        • Goldhaber S.Z.
        • et al.
        Right heart thrombi in pulmonary embolism: results from the International Cooperative Pulmonary Embolism Registry.
        J. Am. Coll. Cardiol. 2003; 41: 2245-2251https://doi.org/10.1016/s0735-1097(03)00479-0
        • Naeem K.
        Floating thrombus in the right heart associated with pulmonary embolism: the role of echocardiography.
        Pak J Med Sci. 2015; 31: 233-235https://doi.org/10.12669/pjms.311.6219
        • Shah D.P.
        • Min J.K.
        • Raman J.
        • Lodato J.A.
        • Van Kley D.
        • Lang R.M.
        • et al.
        Thrombus-in-transit: two cases and a review of diagnosis and management.
        J. Am. Soc. Echocardiogr. 2007; 20: e6-e8https://doi.org/10.1016/j.echo.2007.01.041
        • Konstantinides S.V.
        • Meyer G.
        • Becattini C.
        • Bueno H.
        • Geersing G.J.
        • Harjola V.P.
        • et al.
        2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS).
        Eur. Respir. J. 2019; 541901647https://doi.org/10.1183/13993003.01647-2019
        • Athappan G.
        • Sengodan P.
        • Chacko P.
        • Gandhi S.
        Comparative efficacy of different modalities for treatment of right heart thrombi in transit: a pooled analysis.
        Vasc. Med. 2015; 20: 131-138https://doi.org/10.1177/1358863X15569009
        • Rosendaal F.R.
        • Reitsma P.H.
        Genetics of venous thrombosis.
        J. Thromb. Haemost. 2009; 7: 301-304https://doi.org/10.1111/j.1538-7836.2009.03394.x
        • Simone B.
        • De Stefano V.
        • Leoncini E.
        • Zacho J.
        • Martinelli I.
        • Emmerich J.
        • et al.
        Risk of venous thromboembolism associated with single and combined effects of Factor V Leiden, Prothrombin 20210A and Methylenetethraydrofolate reductase C677T: a meta-analysis involving over 11,000 cases and 21,000 controls.
        Eur. J. Epidemiol. 2013; 28: 621-647https://doi.org/10.1007/s10654-013-9825-8